Monkeybone

Brendan Fraser

Stu Miley

Bridget Fonda

Dr. Julie McElroy

John Turturro

Monkeybone (voice)

Chris Kattan

Organ Donor Stu

Giancarlo Esposito

Hypnos

Rose McGowan

Miss Kitty

Dave Foley

Herb

Megan Mullally

Kimmy Miley

Bob Odenkirk

Head Surgeon

Whoopi Goldberg

Death

Pat Kilbane

Burger God Representative

Lisa Zane

Medusa

Sandra Thigpen

Alice

Wayne Wilderson

Hutch

Amy Higgins

Clarissa