Paulie

Gena Rowlands

Ivy

Tony Shalhoub

Misha Vilyenkov

Cheech Marin

Ignacio

Bruce Davison

Dr. Reingold

Trini Alvarado

Adult Marie Alweather

Jay Mohr

Benny / Paulie (voice)

Buddy Hackett

Artie

Hallie Eisenberg

Marie Alweather

Matt Craven

Warren Alweather

Bill Cobbs

Virgil the Janitor

Tia Texada

Ruby / Lupe (voice)

Laura Harrington

Lila Alweather

?

Peter Basch

Graduate Student #1

?

Emily Mura-Smith

Graduate Student #2

?

Hal Robinson

Grandpa